| Game Title | Country | Year | Publisher |
| Sky Ace | TW | 1993 | Sachen |
| Street Rider | TW | 1993 | Sachen |
| SaGa 2 - Hihou Densetsu | Unknown | ||
| Sanrio Carnival | Unknown | Unknown | Unknown |
| Sonic 3D Blast 5 | Unknown | Unknown | Unknown |
| Spiritual Warfare | Unknown | Unknown | Unknown |
| Spirou | Unknown | Unknown | Unknown |
| Splitz | Unknown | Unknown | Unknown |
| Super Ayanami Discovery Slide Show | Unknown | Unknown | Unknown |
| Super Bikkuriman - Densetsu no Sekiban | Unknown | Unknown | Unknown |
| Super Color - Advance 46-in-1 All USA Version | Unknown | Unknown | Unknown |
| Super Robot Taisen | Unknown | Unknown | Unknown |
| Supreme 105-in-1 | Unknown | Unknown | Unknown |
| SeaQuest: DSV | US | Nov-94 | Malibu Games |
| Serpent | US | Nov-90 | Taxan |
| Shanghai | US | Jun-90 | HAL Laboratory |
| Shaq Fu | US | Oct-95 | Black Pearl Software |
| Side Pocket | US | Nov-90 | Data East |
| Skate Or Die: Bad 'N Rad | US | Sep-90 | Konami |
| Skate Or Die: Tour de Thrash | US | Jun-91 | Electronic Arts |
| Small Soldiers | US | Nov-98 | THQ |
| Sneaky Snakes | US | Jun-91 | Tradewest |
| Snoopy's Magic Show | US | Oct-90 | Seika |
| Snow Bros. Jr. | US | Jan-92 | Capcom |
| Soccer Mania | US | Mar-92 | Sony Imagesoft |
| Solar Striker | US | Feb-90 | Nintendo |
| Solitaire FunPak | US | Nov-94 | Interplay |
| Solomon's Club | US | Apr-91 | Tecmo |
| Space Invaders: The Arcade Game | US | Oct-94 | Nintendo |
| Spanky's Quest | US | Jul-92 | Natsume |
| Speedball II | US | Oct-92 | Mindscape |
| Speedy Gonzales | US | Jul-93 | Sunsoft |
| Spider-Man & X-Men: Arcade's Revenge | US | Dec-93 | LJN |
| Sports Illustrated Championship Football & Baseball | US | Oct-93 | Malibu Games |
| Sports Illustrated for Kids: The Ultimate Triple Dare | US | Apr-94 | Malibu Games |
| Sports Illustrated Golf Classic | US | Oct-94 | Malibu Games |
| Spot | US | Sep-91 | Virgin Interactive |
| Spot's Cool Adventure | US | Jan-93 | Virgin Interactive |
| Spud's Adventure | US | Jun-91 | Atlus |
| Spy vs. Spy: Operation Booby Trap | US | Sep-92 | Kemco |
| Square Deal | US | Apr-92 | DTMC |
| Star Hawk | US | Jun-93 | Accolade |
| Star Trek - 25th Anniversary | US | Feb-92 | Ultra Soft |
| Star Trek - The Next Generation | US | Jun-93 | Absolute |
| Star Trek Generations - Beyond the Nexus | US | Nov-94 | Absolute |
| Star Wars | US | Nov-92 | Nintendo |
| Star Wars - Super Return of the Jedi | US | Nov-95 | Black Pearl Software |
| Star Wars - The Empire Strikes Back | US | Jan-93 | Capcom |
| Stargate | US | Dec-94 | Acclaim |
| Stop That Roach! | US | Jul-94 | Koei |
| Street Fighter II | US | Sep-95 | Nintendo |
| Street Racer | US | Dec-96 | UBI Soft |
| Sumo Fighter | US | Mar-93 | DTMC |
| Super Battletank | US | Apr-94 | Absolute |
| Super Black Bass | US | Nov-98 | Hot-B |
| Super Chase HQ | US | Jan-94 | Taito |
| Super Hunchback | US | Apr-92 | Ocean |
| Super Mario Land | US | Aug-89 | Nintendo |
| Super Mario Land 2: 6 Golden Coins | US | Nov-92 | Nintendo |
| Super Off Road | US | Nov-92 | Tradewest |
| Super R.C. Pro-Am Racing | US | Oct-91 | Nintendo |
| Super Scrabble | US | Mar-91 | Milton Bradley |
| Superman | US | Dec-97 | Titus |
| Swamp Thing | US | Oct-92 | THQ |
| Samurai Shodown | US | Nov-94 | Takara |